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Topics - More Than Mortal
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751
« on: May 31, 2015, 04:32:34 PM »
A bit of a more light-hearted topic, admittedly, but I'd just be interested to see which user you think you are most similar to in your political opinions. Also, who do you think you're furthest from?
I'd probably say I'm closest to Turkey, and furthest from Verbatim.
752
« on: May 31, 2015, 03:30:04 PM »
Just give a brief sentence of your views on each of these issues. I'm not looking for sage-like wisdom; even if you're completely ignorant, I'd like to know what your nonetheless ignorant views are on the matter. Vietnam War: Spoiler Largely justified; the Vietnam war is viewed as a failure mainly because public opinion tanked, despite the fact the real failure was after the war when the American government failed to live up to the peace accords. Iraq War: Spoiler Again, largely justified, despite the obvious blunders. The Iraqi people--especially the Kurds--will be better off in the long-run as a result of the war. Inflation vs. Unemployment (which is the most important thing to target?): Spoiler Unlike most conservatives, I'm not very hawkish on inflation. Rates of inflation approaching 10pc wouldn't scare me, assuming the right circumstances. But neither is unemployment a good target. I think the best course of action is to keep the level of nominal spending constant. European Union: Spoiler A horribly bureaucratic institution with a clear lust for power; should be dismantled immediately. As well as its failure of a pet project, the Euro. The Council of Europe is a much better template for European co-operation. Punishment vs Rehabilitation: Spoiler Of the two, rehabilitation is the most important. I do think it would be wise to note, however, that as much as half of violent offenders simply can't be rehabilitated. Almost certainly one-sixth cannot be rehabilitated in any reasonable timespan. Drug legalisation: Spoiler I favour the legalisation of all drugs, with graded regulations depending on the severity of the drug. Tax: Spoiler Corporate tax should be abolished outright, as should inheritance tax. Income tax should be drastically lowered and more emphasis should be placed on sales and property taxes; I could see something like a marginal rate of 80pc for sales taxes being justifiable. Pensions/Social security: Spoiler Should be defunded and shifted to private accounts immediately. Bank regulation: Spoiler Banks should be broadly deregulated and the government should take a massive step back from the financial system. Essential regulations like capital and liquidity requirements, publicly available plans-of-action should a bank be forced to close and the end of TBTF should have much more emphasis. These are all that come to mind, for the time being.
753
« on: May 31, 2015, 02:59:23 PM »
As many Bongs will know (especially Mr P.), the NHS is a fucking religion over here. Mention anything even vaguely suggestive of not having the NHS completely operated by the government and suddenly you're some big business, corporatist shill. All of this despite the fact that the NHS is a relatively bad healthcare system (God help you if you're a politician and say that, though) and that most of the best forms of healthcare are more oriented towards competition and have less gate-keeping. Personally, I favour Social Health Insurance, as in Germany, Switzerland and the Netherlands.
754
« on: May 30, 2015, 04:55:21 PM »
How anybody can support her is utterly beyond me. Not only do certain facets of the media seem to hold them to lower standards (specifically Stephanopoulos's duplicity in interviewing Peter Schweizer), but they seem eager to shoot down any criticism in the most facile and unintelligent ways. Not, of course, that this isn't a staple of the media in general. The IBT broke the story that regimes which donated to the Clinton Foundation received a spike in arms deals while Clinton was Secretary of State. And Slate, of course, jumps into the fray claiming that there is no "smoking-gun evidence" of a quid pro quo transaction. Which is a perfectly valid observation to make, but when it comes to who will be sitting in the White House, are you willing to play chicken? We know that Bill Clinton gave eleven speeches during Hillary's time as Secretary, each connected to certain companies with pending business before the dept., and all of which were concluded favourable for each connected company. And, of course, we have people like the insufferable Nick Kristof making proclamations about how the Clintons' greed is actually driven by a political system which needs money as an incessant form of fuel; yet the idea that the Clintons are making $700,000 speeches in countries like Nigeria (with connections to those aforementioned companies) to "fuel their campagin" is ridiculous, especially since the Clinton Foundation pays for all their travel expenses. We've already had one duplicitous Clinton at the helm, let's not have another.
755
« on: May 30, 2015, 03:49:49 PM »
Bryon York noticed something peculiar about Bernie Sander's announcement speech: the stark lack of Michael Brown, Baltimore, Freddie Gray or indeed any racial issue. Or gender-based issue, for that matter, besides passing references. And why is this? Unlike the liberal "establishment" of modern politics, Sanders doesn't actually lend any credence to identity politics. He's an old socialist; one who views social ills as by-products of an inherently unjust market system. I may disagree with his conclusions, but I'll give him credit for his sincerity. Were I voting in a Democratic primary, I'd choose him just to spite the Clintons.
756
« on: May 30, 2015, 01:32:44 PM »
. . . As well as some police attention.
I recently got an air rifle and took it down the local shooting supplies store to get the sights sorted and buy some .22 pellets. Afterwards, my mom was putting some shopping in the boot and I had to hold the rifle while she sorted everything out, and some bitch flagged down a copper.
Nice rifle, though.
757
« on: May 29, 2015, 03:09:16 PM »
After following the news on it for a while, and initially being a strong opponent of the Patriot Act and the NSA's metadata collection programme, I consider myself in favour of it's actions. The empirical evidence seems to suggest that it is an asset to national intelligence, not a violation of the Fourth Amendment nor a violation of privacy.
758
« on: May 29, 2015, 09:36:16 AM »
National ReviewIn 8 a.d., Ovid, the poet, the toast of Rome, was suddenly exiled to the remote outpost of Tomis. The reason remains a mystery. Ovid himself said only that his fate was caused by carmen et error — “a poem and a mistake.”
Two millennia later, a new effort to exile Ovid — not from Rome, but from Columbia University’s famed Core Curriculum — could be attributed to the same: carmen et error, where the poem is his Metamorphoses, and the error is that “like so many texts in the Western canon, it contains triggering and offensive material that marginalizes student identities in the classroom. These texts, wrought with histories and narratives of exclusion and oppression, can be difficult to read and discuss as a survivor, a person of color, or a student from a low-income background.” So wrote four undergraduate students earlier this month in Columbia’s campus newspaper, the Spectator. They would like a “trigger warning” affixed to Ovid’s masterwork.
It is safe to say that these students (all members of Columbia’s “Multicultural Affairs Advisory Board,” by the by) overreached. Critics have been many and swift and savage. In her weekly Wall Street Journal column, Peggy Noonan pardoned the students on the grounds that “everyone in their 20s has the right to be an idiot.”
But idiocy is notoriously infectious, and it is not obvious that the obvious rebuttals will suffice. For instance, critics have posed the natural reductio question, namely: If Ovid merits a “trigger warning,” doesn’t Shakespeare? Milton? Chaucer? The Bible? (Yes, yes, yes, and it doesn’t have one already?) But appealing to the power of Great Names — Shakespeare! — or repairing to mockery are sufficient responses only as long as a Great Name has the power to inspire awe, or mockery to inspire shame.
One cannot assume either today. The “trigger warning” crowd has placed the past on the defensive. The text must submit to the reader, not the other way around. Or as Columbia’s op-ed writers put it: “Students need to feel safe in the classroom, and that requires a learning environment that recognizes the multiplicity of their identities.”
Notably, Columbia’s administration has played somewhat into this view. On the website for its Core Curriculum, Ovid is advertised as “a particularly modern poet. He knew how to take genres apart, recognizing and exposing their codes and patterns,” writes Classics professor James Uden. “Then he delighted in reassembling them in surprising ways.” The Metamorphoses is itself “a radical kind of epic poem.” So, to students who have said, “Look how old and primitive and cruel Ovid is! He is nothing like us, which is why we should not read him!” Columbia has responded, “Look how fresh and contemporary and subversive Ovid is! He’s just like us, which is why we should read him!”
In an age in which quashing dissent in political and cultural life is increasingly the norm, Columbia’s response is alarming. Maybe Ovid is old, primitive, and cruel (he’s not, but let’s say so for argument’s sake); he is still different. And that’s increasingly important.
In an introductory essay to St. Athanasius’s De Incarnatione (another very old book), C. S. Lewis made just this argument. “Every age has its own outlook,” wrote Lewis. “It is specially good at seeing certain truths and specially liable to make certain mistakes. We all, therefore, need the books that will correct the characteristic mistakes of our own period. And that means the old books.”
Lewis is not suggesting (at least not here) that old books got things more right than new ones — Dante was not omniscient — but simply that they got things right (and wrong) differently: “Two heads are better than one, not because either is infallible, but because they are unlikely to go wrong in the same direction.”
Particularly in an age obsessed with “diversity,” such an observation is timely. Even a class of twentysomethings who hail from both Harlem and the Hamptons are likely to exhibit a consensus on a whole swath of fundamental questions. But older writers, not brought up in 21st-century America, won’t. They will think differently. They will use unfamiliar words in unfamiliar constructions; they will combat unfamiliar enemies and call upon unfamiliar friends; they will wrestle with unfamiliar questions and offer unfamiliar answers.
And that unfamiliarity is the point. Reading old books is a way of resisting the cultural and intellectual uniformity that develops when one’s intellectual horizon is one’s own birthdate. A great deal of such uniformity is evident in modern American political and cultural and intellectual life.
Being able to stand outside of it, to offer a detached and learned perspective on our present discontents, is much of the reason for education in the first place. Colleges that seek to turn out original thinkers, persons not bounded by their own time who can offer that substantive critique, are rare. But they remain — as do students up to the challenge.
Any of those students who attend Columbia may want to consider transferring.
759
« on: May 28, 2015, 05:08:17 PM »
Fuck me.New York police allegedly arrested two men for “manspreading” (sitting with their legs far apart) on the subway, according to a report entitled “That’s How They Get You” released by the Police Reform Organizing Project.
“On a recent visit to the arraignment part in Brooklyn’s criminal court, PROP volunteers observed that police officers had arrested two Latino men on the charge of ‘man spreading’ on the subway, presumably because they were taking up more than one seat and therefore inconveniencing other riders,” the report states.
Metro Transit Authority rules ban people from taking up more than one seat “in a station, platform or conveyance when to do so would interfere or tend to interfere with the operation of the Authority’s transit system or the comfort of other passengers.”
MTA also placed signs on subway cars in December instructing people not to “manspread” as part of a larger campaign to encourage riders to be polite, which also included signs telling people not to hog poles or do their makeup on the train. The “no manspreading” rule in particular, however, got most of the publicity after feminist activists attacked “manspreading” as being not just rude and/or annoying but actually oppressive to women.
Now there’s no doubt that some dude taking up enough room for two people on a crowded train is annoying — but the report claims that the arrests occurred late at night, when the train probably would have been pretty empty: “Before issuing an [adjournment contemplating dismissal] for both men, the judge expressed her skepticism about the charge because of the time of the arrests: ‘12:11AM, I can’t believe there were many people on the subway.”
Of course, even if the train was super crowded, it seems as though simply asking the men to move over might have been a more reasonable option. As the report itself also notes, however, our current system demands that officers meet quotas and therefore directly discourages them from seeking other solutions to problems — whether or not those would be reasonable. In fact, the report even claims that in some cases officers had admitted that the quota policy was their reason for making an arrest.
All-in-all, the report listed nearly 120 allegations of abuse, including one claim that a Latino teenager was charged for having a backpack next to him on the train, and that officers “arrested him — cuffed and confined him overnight — when they ran a check and found that he had an outstanding warrant for skateboarding in a Middle Village, Queens park after dark.”
PROP president Robert Gangi told Newsweek that the organization’s staff and volunteers had observed arraignments for misdemeanors in the four boroughs of the city since June 2014 over the course of about 35 sessions lasting a few hours. The observers found, according to the report, that “out of the 850 total cases seen, 797, or about 94 percent, of the defendants were people of color. 756 people, or 89 percent, of the persons arrested or ticketed were able to walk out of the courtroom.” Fucking Jesus.
760
« on: May 28, 2015, 04:15:05 PM »
Just found this article in the National Review.The Middle East is in meltdown.
The Syrian civil war is unrestrained. Tens of thousands have died. Saudi Arabia and Turkey are considering direct intervention. Syria’s mayhem threatens to spill into Lebanon, and in Beirut, Iran and Hezbollah wage terrorism against their political opponents.
Jordan is overwhelmed by a refugee crisis of staggering proportions. Iraq teeters on the brink of collapse. Its government remains divided and weak. Unsupported by America, the Sunni tribes are wedged between the jackboot of Iran and the horrors of ISIS.
Yemen is a Mad Max battleground between Saudi Arabia and Iranian-supported Houthi rebels (and nationalists, separatists, and al-Qaeda).
But while the operative cause of this disaster is authoritarianism and the rot of political Islam, President Obama’s strategy is certainly catalyzing the catastrophe. And now, thanks to his delusion, the chaos is about to get a thermonuclear injection. Just read what one Gulf leader currently visiting Washington told the New York Times: “We can’t sit back and be nowhere as Iran is allowed to retain much of its capability and amass its research.”
The Saudis have made themselves clear. As I explained in February, Iran’s acquisition of a nuclear capability will lead to reciprocal action by the Saudi government. After all, Saudi Arabia’s long-term financial support for Pakistan’s nuclear program has never been just about Islamic beneficence. Instead, that funding was a down payment for future opportunity.
This speaks to the great failing of President Obama’s Middle East policy: its narrow focus.
President Obama believes rapprochement with Iran is fostered by his tangible support for the more moderate elements of that regime. But he neglects two undeniable facts. First, Iran’s policy toward the United States is shaped not only by deep mistrust but also by outright hatred. To be sure, President Obama has forged trust with more-moderates like Foreign Minister Zarif and President Rouhani. Yet he has neglected the simultaneous need to deter regime hard-liners who hate America and hold great influence over the Supreme Leader, Ayatollah Khamenei. Today, those hard-liners are empowered by President Obama’s strategic hesitation.
Don’t believe me? Just look at what they’re doing.
Two weeks ago, Iran seized a Marshall Islands–flagged cargo ship. Last week, an Iranian general said, “We welcome war with the Americans.” This week, the Iranians sent a cargo ship to Yemen to test whether Obama would prevent them from supplying the Houthi rebels. Yesterday, the Iranians fired on a Singapore-flagged cargo ship in the Strait of Hormuz. The U.S. Navy’s response? To send an unarmed plane that arrived too late to do anything. As CNN noted, “The Pentagon recently stopped escorting commercial vessels through the Strait of Hormuz, and it’s not clear if those operations will resume.”
Of course, Iran’s growing hostility was entirely predictable. It’s why I argued a couple of months back that President Obama needed to send another carrier strike group to the Persian Gulf.
Instead, the Obama administration chose to ignore reality. And it still does so. Take John Kerry’s patently ludicrous defense on Tuesday of the Russian-brokered WMD deal with Assad. In return for avoiding U.S. retaliation for his August 2013 massacre at Ghouta, the deal required Assad to surrender his chemical weapons. He hasn’t. Instead, as the Obama administration is well aware, the agreement has not prevented Assad from continuing to burn the lungs of Syrian children. Still, to Kerry, it’s a victory. As he put it, “We have seen what happens when Russia and the United States work together.”
These failures — so brutal and so unambiguous — are the tombstone of U.S. credibility and of our ability to stall the Middle East’s descent into chaos. Iran knows it, and so do our allies. And this, in essence, is why Saudi Arabia will go nuclear. American guarantees are no longer reliable. While President Obama doubles down on vacuous words, others are choosing nuclear weapons. Thoughts? Especially interested in SgtMag's view if he's knocking around at all.
761
« on: May 28, 2015, 12:02:03 PM »
A lot of the literature and proclamations from those on the centre-left is inspired by the Gatsby Curve, which states there is a relationship between the inequality of income distribution and the lack of social mobility. Social mobility is obviously important because it essentially moots the effects, or sense of injustice, of inequality. And, as I'm sure we're all aware, since the 1980s income inequality has widened substantially while social mobility has remained relatively flat. Taking data from a study by Raj Chetty et al. we can see that, when comparing regions in the US, the Gatsby Curve doesn't really hold: There appears to be a much stronger correlation between family structure and social mobility: (Also, anybody interested should check out Robert D. Putnam's Our Kids, which is a great book about the relationship between inequality and family.) Indeed, a 2000 paper by the Federal Reserve found that changing family structure accounted for 52pc of of the increase in the 50-10 ratio, and 49pc of the increase in the 95-5 ratio. Which support's Chetty's (et al) conclusion that the single strongest correlate of upward mobility is the proportion of single-parent families.
762
« on: May 28, 2015, 10:52:48 AM »
It's becoming increasingly clear that China has staked its reputation on success in the South China Sea, and accordingly has adopted a more aggressive and cocksure stance. Diplomacy will not end Chinese aggression, only a clear message from the US. There has been some hope as the Pentagon has apparently been considering more hardline tactics to use against Chinese expansionism in the region, however it seems that the situation is worse than was first thought; the Chinese warned off an American surveillance place at least eight times with the message: "Foreign military aircraft. This is Chinese navy. You are approaching our military alert zone. Leave immediately." Why is this important? Well it's unclear whether or not the aeroplane was actually within the 12 nautical miles of the artificial islands which China considers sovereign territory. If this zone is the same as what the Chinese referred to as the "military alert zone", then it appears that Chinese reassurances over continued navigational freedom are untrue, as they tried to command the US plane while it was in a non-territorial space. There is speculation about whether or not the Chinese will establish an ADIZ over the South China Sea as they did with the East China Sea in 2013; that's besides the point, however, as the Chinese have been challenging American operation within that airspace since 2001, as well as more recently threatening the Philippines. It's no secret that China has been building it up its military with the goal in mind of establishing a regional hegemony, much akin to the actions of Iran, and the artificial islands being constructed in the Sea are being outfitted with runways. The Chinese seem to view geopolitics with a vertical structure of power, where the biggest dogs get the biggest piece of meat. Technically, China has no right to expand its sovereign territory in the way that they have--but they don't seem to care. China has a growing arsenal and collection of military equipment, seemingly tailored to American weaknesses, and will have 40,000 stealth UAVs by 2023; three versions of which will have precision strike capabilities. The Americans need to pick up the slack and move towards the 12-mile zone which the Chinese have claimed as sovereign territory; it isn't a nice choice, since doing so will increase tensions and not doing so would only legitimise the burgeoning Chinese hegemony. Meanwhile, the government continues to sit back and dismantle US military capacity.
763
« on: May 28, 2015, 09:36:14 AM »
The "legal highs" bill of the new Conservative government is probably the worst bill of the lot. It's an unspoken truth that drug users, when denied their choice cut, will simply switch to something else and the recent " explosion" in legal highs seems to bear this out. In June 2008, $7.6bn (or 33 tonnes) of sassafras oil were seized in Cambodia, and the following year ecstasy virtually disappeared from British clubs. And, concurrently, the purity of street cocaine has fallen from 60pc in 2002 to just 22pc in 2009. And, as the quality of ecstasy also decreased, a new drug known as mephedrone began a wave of popularity. Law changes and harsher enforcement in India which led to the drought of ketamine in the UK led to users-- knowingly and unknowingly--taking the substitute known as methoxetamine. And, of course, most legal highs are cannabinoids which seek to replicate the effects of cannabis. Were it the case that cannabis, cocaine and ecstasy not so harshly regulated it's fair to say that these myriad legal highs probably wouldn't exist in the same capacity. The government, however, simply won't tolerate such thinking and so must ban legal highs as they crop up, despite the fact that cannot and never will be able to keep pace with the rate of drug production. When mephedrone was made a Class B drug in 2010, it's no surprise that drugs like NRG-1 and "Benzo Fury" rose up to take its place. So, what is the Conservatives' solution to this? Just fucking ban everything, as the new psychoactive drugs bill will prohibit the trading of "any substance intended for human consumption that is capable of producing a psychoactive effect". Yet we all know that banning something doesn't just make it disappear, an expert panel commissioned by the government acknowledged that the 50pc increase in seizures of Class B drugs in 2012-2014 was driven by the continued sale of mephedrone. And while the usage of mephedrone has fallen compared to pre-ban levels, its purity has plummeted and its street price doubled, as other drugs have come into the market to fill up the slack in usage. I mean, even the Home Office acknowledges that there is no "obvious relationship between the toughness of a country’s enforcement against drug possession, and levels of drug use in that country".
764
« on: May 27, 2015, 06:30:11 PM »
766
« on: May 27, 2015, 05:55:48 PM »
So somebody just sent me this: Well, isn't that dandy? Apart from the fact that it's a heaping shit of misinformation and fallacious reasoning. First of all, Seattle's minimum wage isn't $15 and it's unemployment rate isn't 3.3pc. Seattle's minimum wage is currently $11, as of April, and its unemployment rate is 4.5pc; two big differences. The unemployment rate of King County--of which the city seat is Seattle--is currently 3.3pc and as far as I know KC is subject to WA's state minimum wage of $9.50. Seattle specifically, has seen some negative consequences of the higher minimum wage among narrow-margin businesses. Restaurants and bars have seen declining employment rates and microeconomic inflation is being driven in that sector at around 4-5pc. As the Seattle Times have noted, the employment fall in King County is probably due to seasonal fluctuations. Which, of course, makes sense. A bit of brief research tells me that King County is mostly suburban, meaning its labour market is going to be highly concentrated in services. As the seasonal cycle picks up for the WA economy as a whole, of course high-service areas are going to witness disproportionate employment growth.
767
« on: May 27, 2015, 04:50:54 PM »
Here's a run-down of all the bills.
Welfare benefits bill: - Freezes the main rates of working-age benefits. - Reduces the benefits cap from £26,000 to £23,000.
Enterprise bill: - Cuts £10bn of red tape. - Creates a "Small Business Conciliation Service". - Improves the business rates system. - Caps exit payments to public service workers.
Tax bill: - Bans a rise in VAT, income tax or NI contributions over the next five years.
Childcare bill: - Will provide 30 hours of entitled childcare for 38 weeks of the year.
Housing bill: - Extends the "right-to-buy" scheme. - Requires councils to sell vacant houses. - Introduces a "right-to-build", which includes the construction of 200,000 new social homes and a relaxation of the planning laws.
Energy bill: - Gives local councils, instead of Whitehall, the final say on wind-farm applications.
Immigration bill: - Introduces the offence of "illegal working", and allows the wages of illegal migrants to be seized. - Consultation on funding apprenticeship schemes for British and EU workers by implementing a visa levy on companies using foreign labour.
Trade unions bill: - Introduces a mandatory 50pc turnout for strike ballots. - Will also require a 40pc vote in favour of that 50pc for industrial action to go ahead. - Union members must also opt-in to political donations.
Education and adoption bill: - Gives ministers more power to intervene in "coasting schools" and turn them into academies. - Creates regional adoption agencies to facilitate adoption across local authority boundaries.
Cities and local government devolution bill: - Gives the government the authority to impose mayors on certain areas.
Scotland bill: - Implements the recommendations of the cross-party Smith Commission. This will give the Scottish parliament the power to vary the rates and bands of income tax, greater control over VAT and complete control over air passenger duty. It will also be able to change housing benefit payments.
Wales bill: - Gives the Welsh assembly further powers, including over ports, energy developments, transport regulations, speed limits and sewerage services.
Northern Ireland bill: - Establishes a body called the Historical Investigations Unit to look into unsolved deaths during the Troubles, as the 30 years’ of violence that beset Northern Ireland up to the early 1990s are known.
European Union referendum bill: - Enshrines the promise of an EU referendum before the end of 2017.
Extremism bill: - Given ministers and the police more authority to ban extremist groups.
Investigatory powers bill (AKA Snoopers' Charter): - Makes companies retain metadata for at least 12 months.
Psychoactive substances bill: - Outlaws certain legal highs.
Bank of England bill: - Measures to make the BoE more transparent, requiring it to publish the minutes of MPC meetings alongside interest rate decisions.
Charities bill: - Gives the Charity Commission more powers to disqualify both charities and trustees found guilty of wrongdoing.
Votes for life bill: - Scrapping the system whereby British citizens living overseas lose their votes after 15 years.
The government also plans to bar Scottish MPs from voting on English laws, will introduce seven-day GP services and will raise minimum wage workers out of tax altogether. Out of fear of a backbench rebellion, wording around the scrapping of the Human Rights Act was very vague.
I can't find much to dislike here. I'm particularly a fan of the trade unions bill, the welfare bill and the enterprise bill. However, the BoE bill, psychoactive substances bill, extremism bill and housing bill don't really sit well with me.
Will try and provide more details if anybody is interested.
769
« on: May 27, 2015, 12:50:29 PM »
CUNTS Spoiler i'm going into a line of work involving impressions of verb
770
« on: May 27, 2015, 11:03:52 AM »
The IndependentScientists have the first proof that a “brand new” way of combating cancer, using genetically modified viruses to attack tumour cells, can benefit patients, paving the way for a “wave” of new potential treatments over the next decade.
Specialists at the NHS Royal Marsden Hospital and the Institute of Cancer Research (ICR) confirmed that melanoma skin cancer patients treated with a modified herpes virus (the virus that causes cold sores) had improved survival – a world first.
In some patients, the improvements were striking. Although all had aggressive, inoperable malignant melanoma, those treated with the virus therapy – known as T-VEC – at an earlier stage survived on average 20 months longer than patients given an alternative.
In other patients results were more modest, but the study represents a landmark: it is the first, large, randomised trial of a so-called oncolytic virus to show success.
Cancer scientists predict it will be the first of many in the coming years – adding a new weapon to our arsenal of cancer treatments.
The method – known as viral immunotherapy – works by launching a “two-pronged attack” on cancer cells. The virus is genetically modified so that it can’t replicate in healthy cells – meaning it homes in on cancer cells.
It multiplies inside the cancer cells, bursting them from within. At the same time, other genetic modifications to the virus mean it stimulates the body’s own immune response to attack and destroy tumours.
Other forms of immunotherapy – the stimulation of the body’s own immune system to fight cancer – using antibodies rather viruses, have been developed into successful drugs. It is hoped that T-VEC could be used in combination with these.
Findings from trials of T-VEC, which is manufactured by the American pharmaceutical company Amgen, have already been submitted to drugs regulators in Europe and the USA.
Viral immunotherapies are also being investigated for use against advanced head and neck cancers, bladder cancers and liver cancers.
Kevin Harrington, UK trial leader and professor of biological cancer therapies at the ICR and an honorary consultant at the Royal Marsden, said he hoped the treatment could be available for routine use within a year in many countries, although it would need to pass the UK’s own regulatory approval before it could be prescribed here.
“I hope, having worked for two decades in this field, that it really is the start of something really exciting,” said Professor Harrington. “We hope this is the first of a wave of indications for these sorts of [cancer fighting] agents that we will see coming through in the next decade or so.”
Professor Paul Workman, chief executive of the ICR said: “We may normally think of viruses as the enemies of mankind, but it’s their very ability to specifically infect and kill human cells that can make them such promising cancer treatments.”
The study, which is published in the Journal of Clinical Oncology, included 436 patients, all of whom had aggressive, inoperable malignant melanoma. More than 16 per cent of patients were responding to treatment after six months, compared to 2.1 per cent who were given a control treatment.
Some patients were still responding to treatment after three years.Alan Melcher, professor of clinical oncology and biotherapy at the University of Leeds, and an expert in oncolytic viruses, said the field had accelerated quickly in recent years.
“They were first developed to go in and kill cancer cells but leave other cells unharmed. What’s become clear is that these viruses may do that but what is probably more important, is that they work by stimulating an immune response against cancer,” he said.
“The field has moved very quickly clinically. Immunotherapy looks promising and big pharmaceutical companies are now involved. Amgem have bought this virus and the reality is, when the big companies get involved things move a lot more quickly.”
Dr Hayley Frend, science information manager at Cancer Research UK, said the potential for viruses in future cancer treatments was “exciting”.
“Previous studies have shown T-VEC could benefit some people with advanced skin cancer but this is the first study to prove an increase in survival. The next step will be to understand why only some patients respond to T-VEC, in order to help better identify which patients might benefit from it,” she said.
Melanoma is the fifth most common cancer in the UK, and is becoming more widespread as a result of increased exposure to the sun in younger generations who have benefitted from easier access to sunnier climates on holiday. Survival chances are good if the cancer – indicated by the appearance of a new mole on the skin – is caught early.
However, if left alone, the tumour can become inoperable, and 2,000 people still die from melanoma in the UK every year.
771
« on: May 27, 2015, 10:49:40 AM »
The Financial Times.Both al-Qaeda and ISIS have seen more than 25,000 Mujahideen which creates an "unprecedented threat to national and international security in both the “immediate and long-term” that most governments have failed to grasp the significance of so far." The report made by the UN Security Council is based on "robust and detailed" evidence from 27 intelligence agencies across member states, which details a a dramatic change over the last three years in the number of Mujahideen joining militant Sunni groups--up from just a couple thousand a decade ago. “The number of countries of origin has also significantly increased . . . from a small group of countries . . . to more than 100 member states, including countries that have never experienced problems with groups associated with al-Qaeda.”
“The trend line remains worrying,” the report adds, noting a 70 per cent increase in the total number of foreign fighters since March 2014. The problem is overwhelmingly focused on Iraq and Syria. Turkey remains the country through which jihadis are gaining access to Syria and Iraq, along with the two groups. The global response has so far been inadequate, with one ex-spy chief saying that Islamic terrorism in the Middle East is the greatest security threat to Europe since the Cold War. The main barrier to international success against terrorism is the lack of intelligence sharing, as “less than 10 per cent of basic identifying information has made it into global multilateral systems to date.”
772
« on: May 26, 2015, 04:59:45 PM »
I've had a couple of cheeky tugs in classrooms when I was required to stay after school ended.
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« on: May 26, 2015, 04:31:05 PM »
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« on: May 26, 2015, 03:59:57 PM »
PaperAbstract: Persistently increasing wage inequality, polarization of the wage distribution, and stagnating real wages for low skill workers are some of the most salient features of modern labor markets, but are difficult to reconcile with the theoretical literature on economic growth. To better understand the mechanisms driving these phenomena, we construct an endogenous growth model of directed technical change with automation (the introduction of machines which replace low-skill labor and complement high-skill labor) and horizontal innovation (the introduction of new products, which increases demand for both types of labor). The economy endogenously follows three phases: First, both low-skill wages and automation are low, while income inequality and the labor share are constant. Second, increases in low-skill wages stimulate investment in automation, which depresses the growth rate of future low-skill wages (potentially to negative), and reduces the total labor share. Finally, the share of automated products stabilizes and low-skill wages grow at a positive but lower rate than high-skill wages. Adding middle skill workers allows the model to generate a phase of wage polarization after one of uniform increase in income inequality. We show that this framework can quantitatively account for the evolution of the skill premium, the skill ratio and the labor share in the US since the 1960s
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« on: May 25, 2015, 01:54:44 PM »
It's Memorial Day in the US at the moment; while not a holiday in Britain, but it is nevertheless something I privately participate in. As Churchill said following the Battle of Britain, never has so much been owed by so many to so few. And while the nations of the West have their issues, they have also demonstrated their civilisation and moral superiority; whether it be triumph over Nazism, or the current fight against terrorists who fundamentally oppose our culture and values.
However ambivalent our victories may have been, or will be, we nevertheless honour those who died in defence of civilisation. Not just democracy, not just for King and country, not just for blind patriotism--but for the defence of civil society and freedom for all. Blunders and mistakes have been made, leaders drawn us astray and militaries misused throughout history. But, ultimately, the sacrifice of our soldiers embodies a willingness to maintain the security of our society against all manner of threats.
And to those who have died on the front of whichever war, may you rest in peace. Whether or not your specific sacrifice was ultimately for a good cause is immaterial now, and your death is nevertheless remembered by we, the living.
They shall grow not old, as we that are left grow old. Age shall not weary them, nor the years condemn. At the going down of the sun, and in the morning, We will remember them.
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« on: May 25, 2015, 12:41:42 PM »
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« on: May 25, 2015, 12:21:34 PM »
Because it is 'unkind'The Boy Scouts of America, an organization with semi-military origins, has put out approved activities for its members, and water gun fights are strictly prohibited.
A blog for the organization’s leaders said May 6 that pointing simulated firearms at people is not allowed.
“Why the rule? A Scouter once told me this explanation I liked quite a bit: A Scout is kind. What part of pointing a firearm [simulated or otherwise] at someone is kind?” said Bryan Wendell on the scouting website.
The rule is clarified in the Boy Scouts of America National Shooting Manual, which says “For water balloons, use small, biodegradable balloons, and fill them no larger than a ping pong ball. […] Water guns and rubber band guns must only be used to shoot at targets, and eye protection must be worn.”
The manual includes a lengthy list of other prohibited items — boomerangs, crossbows, potato guns, spear guns and throwing stars. Scouts also may not use “marshmallow shooters that require placing a straw or similar device in the mouth.”
The Scouting movement began in the early 20th century Britain under the tutelage of Lt. Gen. Robert Baden-Powell, who wrote the first “Scouting for Boys” manual.
Baden-Powell learned from his military experiences in India and southern Africa that young soldiers often lacked outdoor-survival skills. He also cited the Mafeking Cadet Corps, a group of adolescent and pre-adolescent boys that he used to great success during the Second Boer War siege of that town. The boys eagerly took on such essential military duties as couriers and intelligence, freeing older soldiers for more-demanding tasks.
Numerous critical journalists and bloggers noted that Scouting when they were boys included such activities as bottle rockets, wooden sword fights and Midnight Football, which a Gawker author described as “a sort of combat rugby played in blackout conditions on a hard tile floor.”
Negative feedback flowed into the comments section of the blog, complaining of political correctness, of “turning boys into a bunch of wusses,” and of an out-of-touch national leadership.
“This makes BSA look ridiculous and has little if any impact on safety,” said Gary Holeiwnski.
“Sometimes I just have to laugh out loud at how idiotic some things in our society have become. We can’t squirt each other with water guns because it is a ‘simulated’ gun. I can’t believe BSA is so worried about the PC police that it has a policy like this,” added commenter Gary USMC.
“Yes, let’s carry every policy to the absurd extreme. That will certainly help scouts shed that geeky image,” added another commenter.
The Boy Scouts of America National Shooting Manual guidelines are to be followed by anyone involved with Cub Scouting, Boy Scouting, Venturing, Sea Scouting, or shooting sports committees, the document adds. The world is fucking insane.
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« on: May 24, 2015, 03:01:49 PM »
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« on: May 24, 2015, 01:44:19 PM »
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« on: May 24, 2015, 01:14:20 PM »
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