Entropy, the tendency for systems to break down, lose energy and disperse is conceivably countered (big emphasis on conceivably) by the actions of molecules forming into ever more complex systems. Also known as life. As life expands and evolves, it it possible (not probable but possible) that it grows into larger and maybe even smarter systems. Single cell to multiple cell, to self-aware organisms and ecosystems may also follow that pattern of ecosystem to biosphere to Gaia, to Galaxia, increasing in biomass, awareness, stability, and incorporating non-bio-matter into its organized and replicating system. If all/most matter can be incorporated into such a system, it might possibly offset, balance or contain entropy. As to whether or not it could overcome the heat death of the universe? Life better get moving because the arrow of time keeps progressing.
How can entropy be reversed?