Somatic Sex Reprogramming

 
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We knew the world would not be the same.
A few people laughed, a few people cried, most people were silent.
I remembered the line from the Hindu scripture, the Bhagavad-Gita.
Vishnu is trying to persuade the Prince that he should do his duty
and to impress him takes on his multi-armed form and says,
"Now, I am become Death, the destroyer of worlds.."
I suppose we all thought that one way or another.
Yeah it's another gene therapy thread. This is an older one (from 2009) but it's popping up in conversations again, and I figured you guys would have fun with it. I still have yet to see if researchers have tried this on anything beyond mice. Would be interesting to see if someone with the money and interest would bring it back into relevance.

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In science, we don’t often get to talk about male repression, but a new discovery gives us just such a chance. It turns out that ovaries can only remain ovaries by constantly suppressing their ability to become male. Silence a single gene, and adult ovaries turn into testes. That adult tissues can be transformed in this way would be surprising enough, but doing so by changing a single gene is truly astonishing.

As embryos, our gonads aren’t specific to either gender. Their default course is a female one, but they can be diverted through the action of a gene called SRY that sits on the Y chromosome. SRY activates another gene called Sox9, which sets off a chain reaction of flicked genetic switches. The result is that premature gonads develop into testes. Without SRY or Sox9, you get ovaries instead.

But Henriette Uhlenhaut from the European Molecular Biology Laboratory has found that this story is woefully incomplete. Maleness isn’t just forced onto developing gonads by the actions of SRY – it’s permanently kept at bay by another gene called FOXL2.

Uhlenhaut developed a strain of genetically engineered mice, whose copies of FOXL2 could be deleted with the drug tamoxifen. When she did this, she found that the females’ ovaries turned into testes within just three weeks. The change was a thorough one; the altered organs were testes right down to the structure of their cells and their portfolio of active genes. They developed testosterone-secreting Leydig cells, which pumped out as much of the hormone as their counterparts in XY mice. They only fell short of actually producing sperm.

Uhlenhaut found that FOXL2 and SOX9 are mutually exclusive – when one is active, the other is silent and vice versa. The two genes are at opposite ends of a tug-of-war, with sex as the prize. FOXL2 sticks to a stretch of DNA called TESCO, which controls the activity of Sox9. By sticking to TESCO, FOXL2 keeps Sox9 turned off in the adult ovary. Without its repressive hand, Sox9 switches on and sets about its gender-bending antics.

FOXL2 also has a partner-in-repression – the oestrogen receptor, a docking molecule for the hormone oestrogen. The two proteins interact with one another and they cooperate to block Sox9.

The same genes may help to explain the frequent acts of gender-swapping among, fish, reptiles and birds (no, Steve Connor, “one of the great dogmas of biology” is not that “gender is fixed from birth”). In these animals, oestrogens often cause males to change sex into females, and falling levels of oestrogen can trigger the reverse transformation. FOXL2 may also be involved. 

The fact that oestrogen helps to maintain the gender of mice is surprising. Unlike other back-boned animals, mammals are thought to be largely insensitive to levels of sex hormones outside of development. However, Uhlenhaut suggests that oestrogen’s role in keeping ovaries and ovaries may explain why women sometimes appear slightly more masculine after the menopause, a time characterised by falling oestrogen levels.

There have been hints from many species that FOXL2 plays an important role in determining sex. People who inherit faulty copies of the gene can develop a rare disease called BPES that often leads to infertility because of failing ovaries. Goats whose FOXL2 isn’t controlled properly develop a condition called polled intersex syndrome (PIS), where they become males despite carrying two X chromosomes. Females that lack the gene altogether fail to develop proper ovaries at all.

Understanding how gender is set and maintained is vital, for it is such a basic and pervasive element of our lives. Uhlenhaut’s work isn’t just of academic interest. It could also help to treat disorders of sexual development. It could also change how gender reassignment therapies are done, paving the way for gene therapies rather than multiple painful surgeries.
http://scienceblogs.com/notrocketscience/2009/12/16/one-gene-stops-ovaries-from-turning-into-testes/

And the link to the study:
http://www.cell.com/cell/fulltext/S0092-8674(09)01433-0?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867409014330%3Fshowall%3Dtrue


 
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This is not the greatest sig in the world, no. This is just a tribute.
So what I'm getting here
Is that manhood is the natural condition of life
And thus patriarchy is scientifically supported


 
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We knew the world would not be the same.
A few people laughed, a few people cried, most people were silent.
I remembered the line from the Hindu scripture, the Bhagavad-Gita.
Vishnu is trying to persuade the Prince that he should do his duty
and to impress him takes on his multi-armed form and says,
"Now, I am become Death, the destroyer of worlds.."
I suppose we all thought that one way or another.
So what I'm getting here
Is that manhood is the natural condition of life
And thus patriarchy is scientifically supported
Well female is still largely the default blueprint, however it looks as though everyone has the ability to become male. But the starting point for everyone is still female.


 
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This is not the greatest sig in the world, no. This is just a tribute.
So what I'm getting here
Is that manhood is the natural condition of life
And thus patriarchy is scientifically supported
Well female is still largely the default blueprint, however it looks as though everyone has the ability to become male. But the starting point for everyone is still female.
everything ends up male without active resistance. Therefore the end state can be assumed to be default.


 
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I DONT GIVE A SINGLE -blam!- MOTHER -blam!-ER ITS A MOTHER -blam!-ING FORUM, OH WOW, YOU HAVE THE WORD NINJA BELOW YOUR NAME, HOW MOTHER -blam!-ING COOL, NOT, YOUR ARE NOTHING TO ME BUT A BRAINWASHED PIECE OF SHIT BLOGGER, PEOPLE ONLY LIKE YOU BECAUSE YOU HAVE NINJA BELOW YOUR NAME, SO PLEASE PUNCH YOURAELF IN THE FACE AND STAB YOUR EYE BECAUSE YOU ARE NOTHING BUT A PIECE OF SHIT OF SOCIETY
Women don't deserve rights


 
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We knew the world would not be the same.
A few people laughed, a few people cried, most people were silent.
I remembered the line from the Hindu scripture, the Bhagavad-Gita.
Vishnu is trying to persuade the Prince that he should do his duty
and to impress him takes on his multi-armed form and says,
"Now, I am become Death, the destroyer of worlds.."
I suppose we all thought that one way or another.
So what I'm getting here
Is that manhood is the natural condition of life
And thus patriarchy is scientifically supported
Well female is still largely the default blueprint, however it looks as though everyone has the ability to become male. But the starting point for everyone is still female.
everything ends up male without active resistance. Therefore the end state can be assumed to be default.
That's an interesting way to think of it. But removal of the resistance requires advanced medical intervention, so what about that?


 
SecondClass
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What's your damage, Heather?
fuck masculinity


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NK was here. Everything I post is dead serious, no jokes.
I came here from b.net after a few Floods invited me. None of them post on either b.net nor here anymore, which is sad. I was still active on b.net until for some bizarre reason, b.net admins locked out people who have not played Destiny. Even if you wanted to post on the offtopic section. After that, I fully moved here and have not returned to b.net since.
So being a man is the final step of evolution?
wew.


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That's pretty wild. Thanks for posting this, OP.


 
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We knew the world would not be the same.
A few people laughed, a few people cried, most people were silent.
I remembered the line from the Hindu scripture, the Bhagavad-Gita.
Vishnu is trying to persuade the Prince that he should do his duty
and to impress him takes on his multi-armed form and says,
"Now, I am become Death, the destroyer of worlds.."
I suppose we all thought that one way or another.
fuck masculinity
only if you say please


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Da Husk.
If a male goes through gene therapy to become a male will he become an alpha male?


 
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We knew the world would not be the same.
A few people laughed, a few people cried, most people were silent.
I remembered the line from the Hindu scripture, the Bhagavad-Gita.
Vishnu is trying to persuade the Prince that he should do his duty
and to impress him takes on his multi-armed form and says,
"Now, I am become Death, the destroyer of worlds.."
I suppose we all thought that one way or another.
If a male goes through gene therapy to become a male will he become an alpha male?
I doubt you can activate the same gene twice in order to somehow double the effect


 
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This is not the greatest sig in the world, no. This is just a tribute.
If a male goes through gene therapy to become a male will he become an alpha male?
I doubt you can activate the same gene twice in order to somehow double the effect
Yeah, if anything it would cancel out and now you're a woman again.


 
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I DONT GIVE A SINGLE -blam!- MOTHER -blam!-ER ITS A MOTHER -blam!-ING FORUM, OH WOW, YOU HAVE THE WORD NINJA BELOW YOUR NAME, HOW MOTHER -blam!-ING COOL, NOT, YOUR ARE NOTHING TO ME BUT A BRAINWASHED PIECE OF SHIT BLOGGER, PEOPLE ONLY LIKE YOU BECAUSE YOU HAVE NINJA BELOW YOUR NAME, SO PLEASE PUNCH YOURAELF IN THE FACE AND STAB YOUR EYE BECAUSE YOU ARE NOTHING BUT A PIECE OF SHIT OF SOCIETY


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In One are Twelve.
So is there a way for us to flip the switches so to speak? How would that work for an adult male who gets their switch flipped? Do their family jewels morph into family tools?


 
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We knew the world would not be the same.
A few people laughed, a few people cried, most people were silent.
I remembered the line from the Hindu scripture, the Bhagavad-Gita.
Vishnu is trying to persuade the Prince that he should do his duty
and to impress him takes on his multi-armed form and says,
"Now, I am become Death, the destroyer of worlds.."
I suppose we all thought that one way or another.
So is there a way for us to flip the switches so to speak? How would that work for an adult male who gets their switch flipped? Do their family jewels morph into family tools?
Theoretically that would probably be how it works but I don't know if it's been pulled off yet. I'd imagine that exterior ovaries might be a problem.


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You are what you love, not who loves you.
So is there a way for us to flip the switches so to speak? How would that work for an adult male who gets their switch flipped? Do their family jewels morph into family tools?
Theoretically that would probably be how it works but I don't know if it's been pulled off yet. I'd imagine that exterior ovaries might be a problem.
This comes back to the old issue where people assume mutation is a constant for an organism. You would need to alter the every cell's nucleus in turn. The task is insurmountable.