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Serious / Innate Gender Differences
« on: March 17, 2018, 09:21:05 PM »


The Flood / Stephen Hawking dies at 76
« on: March 13, 2018, 11:02:09 PM »

Physicist Stephen Hawking has died at the age of 76, his family has said.

The Briton was known for his groundbreaking work with black holes and relativity, and was the author of several popular science books including A Brief History of Time.

His children, Lucy, Robert and Tim, said: "We are deeply saddened that our beloved father passed away today.

"He was a great scientist and an extraordinary man whose work and legacy will live on for many years."

Stephen Hawking - who died aged 76 - battled motor neurone disease to become one of the most respected and best-known scientists of his age.

A man of great humour, he became a popular ambassador for science and was always careful to ensure that the general public had ready access to his work.

His book A Brief History of Time became an unlikely best-seller although it is unclear how many people actually managed to get to the end of it.

He appeared in a number of popular TV shows and lent his synthesised voice to various recordings.

Stephen William Hawking was born in Oxford on 8 January 1942. His father, a research biologist, had moved with his mother from London to escape German bombing.

Hawking grew up in London and St Albans and, after gaining a first-class degree in physics from Oxford, went on to Cambridge for postgraduate research in cosmology.

As a teenager he had enjoyed horse-riding and rowing but while at Cambridge he was diagnosed with a form of motor neurone disease which was to leave him almost completely paralysed.

As he was preparing to marry his first wife, Jane, in 1964 his doctors gave him no more than two or three years of life.

But the disease progressed more slowly than expected. The couple had three children, and in 1988 - although Hawking was by now only able to speak with a voice synthesiser following a tracheotomy - he had completed A Brief History of Time - a layman's guide to cosmology.

It sold more than 10 million copies, although its author was aware that it was dubbed "the most popular book never read".


Hawking discovered the phenomenon which became known as Hawking radiation, where black holes leak energy and fade to nothing. He was renowned for his extraordinary capacity to visualise scientific solutions without calculation or experiment.

But it was perhaps his "theory of everything", suggesting that the universe evolves according to well-defined laws, that attracted most attention.

"This complete set of laws can give us the answers to questions like how did the universe begin," he said. "Where is it going and will it have an end? If so, how will it end? If we find the answers to these questions, we really shall know the mind of God."

Hawking's celebrity status was acknowledged even by The Simpsons - he was depicted drinking at a bar with Homer, suggesting he might steal Homer's idea that the universe is shaped like a doughnut.

He also appeared as himself in an episode of the BBC comedy series, Red Dwarf and as a hologram of his image in Star Trek: The Next Generation.

The rock group Pink Floyd used his distinctive synthesised voice for the introduction to Keep Talking, on their 1994 album The Division Bell.

Undeterred by his condition, he continued his work as Lucasian Professor of Mathematics at Cambridge University, and in 2001, his second book - Universe in a Nutshell - was published.


He believed his illness brought some benefits; he said before he developed the disease he had been bored with life.

But his condition inevitably made him dependent on others. He often paid tribute to his wife, who had looked after him for more than 20 years, and friends and relatives were shocked when he left her for one of his nurses, whom he married in 1995.

By 2000, Hawking was a frequent visitor to the emergency department of Addenbrooke's Hospital in Cambridge, seeking treatment for a variety of injuries. Police questioned several people about allegations that he had been subjected to verbal and physical abuse over a period of years.

He was known to be an erratic, almost reckless driver of his electric wheelchair, and Hawking insisted his injuries were not caused by abuse. No action was taken.

In 2007, he became the first quadriplegic to experience weightlessness on board the so-called "vomit comet", a modified plane specially designed to simulate zero gravity. He said he did it to encourage interest in space travel.

"I believe that life on Earth is at an ever-increasing risk of being wiped out by a disaster such as sudden nuclear war, a genetically engineered virus, or other dangers. I think the human race has no future if it doesn't go into space. I therefore want to encourage public interest in space."

In 2014, the film The Theory of Everything was released, based on Jane Hawking's account of their courtship and marriage. Hawking himself met Eddie Redmayne as part of the actor's preparation for taking on the role of the scientist.

In a series for the Discovery Channel, he said it was perfectly rational to assume there was intelligent life elsewhere but warned that aliens might just raid earth of its resources and then move on.

He once wrote that he had motor neurone disease for practically all his adult life but said that it had not stopped him having an attractive family and being successful in his work.

"It shows," he said, "that one need not lose hope."

The Flood / I reconnected with my parents
« on: March 10, 2018, 01:11:45 PM »
I figured you guys might be interested in knowing. This forum saw me through some of the worst patches of my life when I got kicked out, so I thought it'd only be fair to share for anyone who was interested.

TL;DR: I was reunited with my family after 4 years of not seeing any of them.

I started getting text messages, and for once they weren't hostile. Eventually the conversation led to my dad offering me a new phone, because mine wasn't working as well as it used to. I didn't even ask, he just asked what kind of phone I had and how well it was preforming, then asked if I was thinking of upgrading soon. I told him that I didn't have the budget and that I still liked my phone even if it wasn't performing the same way it used to because I enjoyed my Note 4 and the utility the stylus provided. I had only owned smart phones with them, so I'd have a hard time using a phone without one. He offered a brand spanking new Galaxy Note 8 which had just come out. "Aren't those phones almost a thousand dollars right now?" He said he found a BOGO deal, and that maybe he could get one for himself too. Immediately my reaction was heavy skepticism, why the hell was he offering me such an expensive phone? I was weary of potential ulterior motives, but I said fuck it. What was he going to do after giving me the phone? Threaten to take it away? He had nothing, and I felt no attachments. So why not? I could benefit from a new phone, and if I didn't really want it or felt weird about the interaction, I could sell for a pretty decent chunk of cash.

So a month or so later after the phone shipped and our schedules aligned, I went to the electronics store we decided to meet at, where they also had the phone case I'd want for it in stock. I didn't realize how nerve wracking this shit would be until I walked through the doors of the store when it hit me. When I spotted him my heart rate spiked so I ducked into another isle and composed myself. I orbited the isle he was in probably about 3 times slowly acclimating myself before I finally approached, and I realized I had the advantage that he didn't recognize me at all to get noticed while doing so.

When I finally worked up the confidence and walked up to him, he was staring at the phone cases and off handedly talking to an employee who went to go search for something. On my drive over he had asked what kind of case I would want, so I sent him the link and told him they should have it in stock. He was standing right in front of it, but had two different cases in his hands. When the employee walked away I came forward and grabbed the case I said I wanted, and as casually as I could said "I think this is the case you were looking for" flipping it over to read the description on the back. He must've thought I was an employee or something at first because he looked over saying "Oh yeah?" and then stuttered upon looking over towards me. " I didn't even realize you were right next to me" Somehow his obvious nervousness made me significantly more comfortable, it was almost as though there was a power shift right in that moment. My father had never been the type to show weakness and vulnerability, and right there for a brief moment I had the upper hand and full control of the situation. "Yeah, I realized you didn't recognize me when you looked at my direction and didn't see me, so I figured I might be able to catch you by surprise" He seemed pretty off guard and told me I looked good, asked for a hug, and then we spent probably the next 10-15 minutes awkwardly talking about phone cases and drop tests, and then just phones in general. I couldn't shake the thought that he felt completely spineless. I don't know why, but it wouldn't get out of my head. The power dynamic was gone, and I felt weirdly confident.

The phone was in the car, he said. So we went to the cash register and paid for the case. They didn't have the tempered glass that would be compatible, so I told him not to worry about it and that I'd buy it off Amazon. He insisted, I said don't worry it's fine. We talk outside the store a bit, and he keeps saying in a surprised tone how I looked healthy. I wasn't really sure what he was implying so I said "Yeah actually I'm easily the healthiest I've ever been in my life, I don't think I've ever felt as good as I do now" he even went to the extent of complimenting my facial hair saying it's better than anything he could grow and was even a bit jealous, and we talked about facial hair for a little while before he said "Okay this is a really weird thing to talk about with you" which irked me a bit but I guess I understood why. "It's only weird because you made it weird" he sort of makes this thoughtful hmph sound and goes to his car to gets the phone, which he hands over with $500. He invited me to lunch, and then we went home.

A few weeks later he asks me how I like the phone, and he tells me how much he's enjoying his. I get invited for dinner at Christmas Eve and he tells me my great grandmother would be there. It took several weeks of thinking about it, and ultimately I agreed to it because I knew I'd probably never forgive myself if I said no to my last opportunity to see my great grandmother. I made it clear that my only terms be that they call me by my legal name and accepted me as their son, and that I would leave and never come back if things turned ugly again. He agreed to the terms.

It was agreed that I'd ride the train halfway down and get picked up from the station. I didn't really anticipate how uncomfortable and nerve-wracking the drive down would be. My father was one thing, but my mother was another. I had no idea what to expect. But nothing really happened. We got there, I was welcomed inside, and there was a weird rush of nostalgia.

My dad's hair is going grey, and something that struck me was how much I looked and sounded like him. My mother's voice oddly sounded much higher pitched than I remembered but that could've just been my perception out of whack since my voice dropped quite a lot. My sister was the same, just older and liked wine a lot. One of the dogs died, and the one who was "my" dog had gone mostly blind, mostly deaf, and barely reacted to seeing me at all. It was really bittersweet since back then the hardest thing about leaving was leaving behind my dog who I had raised since she was a puppy. When she was placed in my lap she kind of just...laid down and went to sleep. It's like she wasn't even the same dog anymore. The third dog, who was my "sister's" dog, was actually extremely excited to see me, but I think seeing how much the dogs aged plus my dad's grey hair made me reflect and realize just how long I'd been gone.

My great grandmother arrived with my grandfather, and they greeted me. Nothing happened. There were no weird questions, no offhand comments. A few accidental slip-ups, but they were immediately followed up with an apology and correction. I had no idea how to react. Who the hell are these people and what did they do to my parents? Seriously, what the fuck happened? I had to of been there for 5 or 6 hours before I finally asked "So did you have any questions?"

We've met a few times since then, mostly for lunch of dinner. Honest to god I had no idea how to cope for a while. I still don't, but since Christmas we've had more serious conversations and they feel sorry. I'm not sure what happened but obviously something made them shift pretty dramatically, because they sure as hell aren't the rabid evangelical control freaks they were when I left. I told them about what I had been doing with myself the last few years, my experience being homeless, all the different people I met and lived with, and my hundreds upon hundreds of hours volunteering for various organizations. They said they failed as parents and that they were proud of me.

That's been my last few months. It's strange and I'm still trying to figure out how to feel about it. Since then they've helped me out with a few things, like picking me up and getting my bike repaired after I got hit by a car who was driving recklessly, and paying for a personal trainer.

So yep.
That's my blog post.

The Flood / Jive give me your wisdom
« on: March 03, 2018, 11:51:54 PM »
I'm on a bulking diet and my stomach hates me. I feel consuming all these calories is way more effort than it should be. I don't feel good, but I think it's because I usually eat pretty healthy. I'm pretty good at self regulating my diet but forcing myself to gain mass through overconsumption is not something I'm enjoying so far.

pls help
how do you eat so much garbage without feeling like death?

The Flood / I'm driving through Glendale
« on: June 19, 2017, 03:44:56 PM »
Deci where you at?

Gaming / New Sonic lets you play as your OC
« on: May 17, 2017, 11:32:03 AM »

If you want to be a neon pink, zebra-striped cat wearing a silver crown, a knockoff Infinity Gauntlet, a heavyweight champion belt, a brown mustache, and yellow flippers, then, I have to say, you have exquisite taste. Also this Sonic game will really appeal to you.

God is dead and we have killed him

The Flood / Deci, I gotta ask
« on: May 14, 2017, 04:57:55 PM »
Serious conversation here, brother to brother.

You sure you're not gay? You talk a lot about dicks and testicles.
Was your ex internet girlfriend a trap?

The Flood / endie my tendies
« on: May 12, 2017, 03:02:03 AM »

Serious / Somatic Sex Reprogramming
« on: April 27, 2017, 01:12:54 PM »
Yeah it's another gene therapy thread. This is an older one (from 2009) but it's popping up in conversations again, and I figured you guys would have fun with it. I still have yet to see if researchers have tried this on anything beyond mice. Would be interesting to see if someone with the money and interest would bring it back into relevance.

In science, we don’t often get to talk about male repression, but a new discovery gives us just such a chance. It turns out that ovaries can only remain ovaries by constantly suppressing their ability to become male. Silence a single gene, and adult ovaries turn into testes. That adult tissues can be transformed in this way would be surprising enough, but doing so by changing a single gene is truly astonishing.

As embryos, our gonads aren’t specific to either gender. Their default course is a female one, but they can be diverted through the action of a gene called SRY that sits on the Y chromosome. SRY activates another gene called Sox9, which sets off a chain reaction of flicked genetic switches. The result is that premature gonads develop into testes. Without SRY or Sox9, you get ovaries instead.

But Henriette Uhlenhaut from the European Molecular Biology Laboratory has found that this story is woefully incomplete. Maleness isn’t just forced onto developing gonads by the actions of SRY – it’s permanently kept at bay by another gene called FOXL2.

Uhlenhaut developed a strain of genetically engineered mice, whose copies of FOXL2 could be deleted with the drug tamoxifen. When she did this, she found that the females’ ovaries turned into testes within just three weeks. The change was a thorough one; the altered organs were testes right down to the structure of their cells and their portfolio of active genes. They developed testosterone-secreting Leydig cells, which pumped out as much of the hormone as their counterparts in XY mice. They only fell short of actually producing sperm.

Uhlenhaut found that FOXL2 and SOX9 are mutually exclusive – when one is active, the other is silent and vice versa. The two genes are at opposite ends of a tug-of-war, with sex as the prize. FOXL2 sticks to a stretch of DNA called TESCO, which controls the activity of Sox9. By sticking to TESCO, FOXL2 keeps Sox9 turned off in the adult ovary. Without its repressive hand, Sox9 switches on and sets about its gender-bending antics.

FOXL2 also has a partner-in-repression – the oestrogen receptor, a docking molecule for the hormone oestrogen. The two proteins interact with one another and they cooperate to block Sox9.

The same genes may help to explain the frequent acts of gender-swapping among, fish, reptiles and birds (no, Steve Connor, “one of the great dogmas of biology” is not that “gender is fixed from birth”). In these animals, oestrogens often cause males to change sex into females, and falling levels of oestrogen can trigger the reverse transformation. FOXL2 may also be involved. 

The fact that oestrogen helps to maintain the gender of mice is surprising. Unlike other back-boned animals, mammals are thought to be largely insensitive to levels of sex hormones outside of development. However, Uhlenhaut suggests that oestrogen’s role in keeping ovaries and ovaries may explain why women sometimes appear slightly more masculine after the menopause, a time characterised by falling oestrogen levels.

There have been hints from many species that FOXL2 plays an important role in determining sex. People who inherit faulty copies of the gene can develop a rare disease called BPES that often leads to infertility because of failing ovaries. Goats whose FOXL2 isn’t controlled properly develop a condition called polled intersex syndrome (PIS), where they become males despite carrying two X chromosomes. Females that lack the gene altogether fail to develop proper ovaries at all.

Understanding how gender is set and maintained is vital, for it is such a basic and pervasive element of our lives. Uhlenhaut’s work isn’t just of academic interest. It could also help to treat disorders of sexual development. It could also change how gender reassignment therapies are done, paving the way for gene therapies rather than multiple painful surgeries.

And the link to the study:

The Flood / please tell us more
« on: April 25, 2017, 01:37:29 AM »
I adore black people and would love to solve racism by gobbling up a big black penis

The Flood / aaaand it's gone
« on: April 23, 2017, 09:38:03 PM »
fuck you cheat I was in the middle of a conversation

The Flood / AMA Alright I'll do one too.
« on: April 10, 2017, 11:34:49 PM »
Mainly since I haven't really been on much the past few months until a few days ago.

New stuff:
-Got a new job
-Got another scholarship
-Haven't gotten a haircut in like 6 months for some reason
-Transbian roommate (mtf lesbian) got the court order for name/gender change
-The other lesbian roommate is still annoying
-The now ex-marine roommate is unemployed
-Gave up on the gym temporarily because work/fuckery with my insurance and testosterone perscription
-I am now an official member of the board meetings for the LGBT center at my college as staff
-Despite my official titles and involvement in the community I'm actually pretty fucking burnt out on LGBT stuff

Serious / Twitter is suing the US government
« on: April 06, 2017, 06:04:13 PM »

Twitter is suing the US government after it demanded it reveal the identity of an anti-Trump account.

The @ALT_USCIS profile was an anonymous profile account criticising President Trump’s immigration policy.

The account claimed it was being run by federal employees at the United States Citizenship and Immigration Services.

Twitter has requested a court block the Trump administration’s request, calling it a matter of free speech.

The challenge was filed in San Francisco, where the micro-blogging service is based.

"The rights of free speech afforded Twitter's users and Twitter itself under the First Amendment of the US Constitution include a right to disseminate such anonymous or pseudonymous political speech,” the company argued.

It added that the government "may not compel Twitter to disclose information regarding the real identities of these users without first demonstrating that some criminal or civil offense has been committed".

The move was backed by the American Civil Liberties Union.

"We are pleased to see Twitter standing up for its users' rights, and the ACLU will soon be filing documents in court on behalf of this user," the ACLU said in an emailed statement.

"To unmask an anonymous speaker online, the government must have a strong justification. But in this case the government has given no reason at all, leading to concerns that it is simply trying to stifle dissent."

Import law

In January, when Donald Trump became President Trump, several so-called "alternative" accounts for US government services began appearing online.

Most claimed to be authored by current or former employees at those agencies, and they offered harsh criticisms of their new boss.

According to the filing, the government sought to use a power given to the US Customs and Border Protection (CBP) - one typically used to obtain records relating to imported merchandise - to get detailed information on who was behind @ALT_USCIS.

The request asked for "all records regarding the twitter account @ALT_USCIS to conclude, User names, account login, phone numbers, mailing addresses, and I.P addresses".

It demanded Twitter hand over the information by 13 March 2017 - though the company was not actually sent the request until the 14th.

In response, Twitter has told the court that "permitting the CBP to pierce the pseudonym of the @ALT _UCCIS account would have a grave chilling effect on the speech of that account in particular and on the many other 'alternative agency' accounts that have been created to voice dissent to government policies".

The account itself tweeted on Thursday the portion of the US Constitution that protects free speech.

Alternative Accounts

The accounts were motivated by the gagging of the official National Parks Service Twitter account which, on the day of President Trump's inauguration, retweeted a picture comparing his crowd size to that of President Obama's inauguration in 2009. It was briefly shut down, before reappearing with an apology for the tweet.

According to press reports at the time, President Trump himself called the head of the National Parks Service to complain.

The furore prompted an apparent "rogue" former employee at the Badlands National Park in South Dakota to commandeer the park's Twitter account to published a variety of statistics and facts relating to climate change.

The tweets were quickly removed and the former worker's access revoked - but not before a flurry of new accounts claiming to be from within agencies appeared.

The veracity of the accounts was hard to verify given the authors insisted on keeping their identities secret in order to protect their jobs.

The Flood / hi
« on: March 27, 2017, 06:10:27 PM »
how's it going

The Flood / Mike Pence horrified to discover unisex toilet in own house
« on: February 25, 2017, 11:09:06 PM »

Vice President and conservative campaigner Mike Pence has today used the power vested to him as Vice President of the United States to issue a proclamation that nobody in his house is allowed to use the unisex toilet adjoining the spare bedroom. Calling the Caroma Uniset liberal propaganda, Mr Pence warned that anyone caught within five meters of the guest room en-suite would be damned to the fires of an eternal hell.

“It’s just not natural” Pence explained to his wife as she urgently hopped back and forth on the balls of her feet. “I’m afraid from now on you’re just going to have to use the women’s bathroom at the park down the road, or hold it in until we visit the mall on Sundays.”

Pence however was quick to clarify that his stance was in no way related to bigotry against women nor was it linked to his deep-seated hatred of trans people. “I’m simply following the teachings of the Bible, and helping others see exactly how Jesus felt about the designation of public bathrooms at schools and local shopping malls,” said Pence. “When God created Adam and Eve he did so with the explicit instruction that they not use the same porcelain lavatories to dispose of their bodily waste. The supreme being is very concerned with these things you know. That’s why he never gets around to solving the whole starving children thing.”

The building will stretch half a mile long, and in it will be a single display in the middle. A single spotlight shining on it, the rest of the building will be dark and empty. Below the spotlight a high resolution photograph of Deci, a collection of his most famous quotes, and a genuine to scale wax sculpture of him, posed into the position of choice by the highest donor.

Start your bids.

The Flood / the jig is up folks
« on: January 30, 2017, 06:21:01 AM »

Serious / Did he do it?
« on: January 29, 2017, 11:40:20 PM »

The Flood / join this muslim discord
« on: January 29, 2017, 02:30:47 PM »

The Flood / Cheat you fucking piece of shit
« on: January 14, 2017, 04:43:17 AM »
get rid of the christmas crap you're making the forum look bad for fuck's sake

I'm showing new people the site and they think it looks like crap because it looks so neglected

The Flood / who needs a new avatar?
« on: January 05, 2017, 11:32:28 PM »

1. post if you want one
2. you don't find out what it is until I post it
3. you have to use the avatar for at least 2 weeks

The Flood / Happy Halloween
« on: December 24, 2016, 06:01:03 PM »
cheat you lazy motherfucker

The Flood / Emoji Movie
« on: December 23, 2016, 05:49:23 AM »
2017 is off to a shitty start already


The Flood / Has science gone too far?
« on: December 11, 2016, 03:56:11 AM »
Tonight's panel will bring in the world's top spiritual scientists to weigh in on this pressing matter.

Stay tuned for fair and balanced updates, this Sunday at 11pm on Fox News

The Flood / Do we have any mormons here?
« on: December 03, 2016, 08:39:26 PM »
we need to find out the mystery of what's in between chally's legs

The Flood / Protip: Never live with lesbians
« on: December 03, 2016, 02:15:39 PM »
Unless you like to hear constant crying and emotional breakdowns for the dumbest possible reasons, passive aggressive feuds, constant nagging towards you and towards themselves, and occasional spontaneous sex that you definitely can't hear through the walls.

The Flood / hey verb
« on: December 01, 2016, 12:59:49 AM »

Gaming / What platform should I buy Doom on?
« on: November 25, 2016, 05:03:32 PM »
I'm super conflicted so help me out here.

Either Xbox or PC.

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