I'm looking to get a simple 2.1 (or just 2.0) setup for my TV, to be able to get input from the TV, my consoles, as well as my PC (I use my TV as a third monitor so I can stream video or play PC games from the couch).

First of all, any recommendations for speakers, amps, or subwoofers would be appreciated. Right now I'm looking at Micca MB42X-C speakers.

But wiring is a bit confusing. Would I connect my Xbox to the amp or sub, or connect everything to the TV and have the TV output the signal to the amp, then to the speakers? Is it even possible to run video from my PC to my TV, then have the PC's audio outputted from the speakers?

Note: I don't have a TV set-top box. I either stream audio to my TV's built in speakers from my PC or I use my Xbox to play Netflix.

Hook a turkey up. Fallout 4 is coming.

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Is it even possible to run video from my PC to my TV, then have the PC's audio outputted from the speakers?

Yes if you have Windows just right click the speaker at the bottom left hand and click playback devices, then select your TV.

That's what I currently do, I was just concerned about having that signal, PC to TV, being able to be outputted from the TV to whatever speaker system I use, which I assume will require a receiver or amp unless I go with a soundbar (and I don't intend to), while also keeping its original channels (left or right unless I go with 5.1) rather than ending up with lossy stereo.